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| Product Name | Platelet Factor 4, Human (PF4) |
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| Description | Purified by Heparin-agarose affinity chromatography. ≥95% pure (SDS-PAGE). Platelet factor-4 (PF-4) is a low molecular weight, heparin-binding protein which is secreted from agonist-activated platelets. PF-4 is localized within the platelet a-granule where its concentration ranges from 11.2-12.4ug per 109 platelets making it, on a molar basis, one of the most abundant proteins in the platelet. Since the relative concentration of PF-4 in platelets exceeds that of plasma by 280,000-fold, PF-4 levels in plasma have been utilized as a measure of platelet activation in vivo. PF-4 is secreted from platelets in complex with a high molecular weight, proteoglycan, carrier protein. Sedimentation equilibrium experiments have shown that in the absence of its proteoglycan carrier, the molecular weight of PF-4 is 27,000-29,000. Subsequent amino acid sequencing of PF-4 revealed a molecular weight of 7,800 indicating that native PF-4 is a homotetramer. Functionally, PF-4 neutralizes the anticoagulant |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | P4258-25D |
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| Order / More Info | Platelet Factor 4, Human (PF4) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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