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| Product Name | Platelet Factor 4, Human (PF4) |
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| Description | Purity ≥95% by SDS-PAGE. Human PF-4 is prepared from the supernatant of thrombin-activated platelets by heparin-agarose affinity chromatography (15). Purity is assessed by SDS-PAGE analysis and heparin-neutralizing activity is verified by clotting assay. Platelet factor-4 (PF-4) is a low molecular weight, heparin-binding protein which is secreted from agonist-activated platelets (1,2). PF-4 is localized within the platelet a-granule (2) where its concentration ranges from 11.2-12.4ug per 109 platelets making it, on a molar basis, one of the most abundant proteins in the platelet (1,2). Since the relative concentration of PF-4 in platelets exceeds that of plasma by 280,000-fold (3), PF-4 levels in plasma have been utilized as a measure of platelet activation in vivo. PF-4 is secreted from platelets in complex with a high molecular weight, proteoglycan, carrier protein (4,5). Sedimentation equilibrium experiments have shown that in the absence of its proteoglycan carrier, the molecular w |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | P4258-25A |
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| Order / More Info | Platelet Factor 4, Human (PF4) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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