| 产品详情 |
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| Product Name | Bmi1-Ring1A E3 Ligase Inhibitor, PRT4165 (2-(Pyridin-3-ylmethylene)-1H-indene-1,3(2H)-dione) |
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| Description | Purity ~99% (HPLC). A cell-permeable indandione compound that inhibits the Bmi1-Ring1A E3 complex ubiquitin ligase activity both in cell-free assays (by 100% against self- and Top2alpha ubiquitination at 25 and 50uM, respectively) and in HeLa cells (by 100% against Bmi1 ubiquitination at 50uM). Shown to greatly potentiate Teniposide (VM26) cancer cytotoxicity (by 10-fold in A375 and A549 cultures at 5.5 and 33uM, respectively) by preventing Top2alpha degradation following VM26 treatment (100% inhibition at 50uM in HeLa cells). Solubility: DMSO Primary Target: BMI1/RING1A Molar Mass: 235.2 |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217223 |
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| Order / More Info | Bmi1-Ring1A E3 Ligase Inhibitor, PRT4165 (2-(Pyridin-3-ylmethylene)-1H-indene-1,3(2H)-dione) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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