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| Product Name | Human Soluble Interleukin 6 Receptor Alpha (sIL6Ra) Protein (Recombinant) |
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| Description | Purity >95% by SDS-PAGE gel and HPLC analyses., MW: 37.9 kDa or 57-70 kDa. IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6Ra and gp130. While the IL-6Ra chain is the binding component specific to IL-6, the gp130 chain only transmits signals of IL-6 when bound to IL-6Ra. The gp130 can also transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6Ra alone. IL-6Ra is expressed in a wide range of cells, including T cells, fibroblasts and macrophages. Soluble IL-6Ra, which consists of only the extracellular domain of the IL-6Ra chain, acts as an agonist of IL-6 activity at low concentrations. PeproTech's CHO cell-derived Recombinant Human sIL-6 Receptor a is a 37.9 kDa glycoprotein corresponding to 339 amino acid residues of the extracellular domain of IL-6Ra. As a result of glycosylation, Recombinant Human sIL-6 Receptor a migrates with an apparent molecular mass of approximately 57-70 kDa by SDS-PAGE gel, under reducing conditions. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | LS-G133797 |
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| Order / More Info | Human Soluble Interleukin 6 Receptor Alpha (sIL6Ra) Protein (Recombinant) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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