| 产品详情 |
| Edit |   |
|---|
| Product Name | JH-II-127 |
|---|
| Description | MW: 416.87. Purity ≥98% by HPLC. JH-II-127 is a highly potent; selective; and cell-permeable LRRK2 inhibitor; with IC50 of 6.6 nM; 2.2 nM; 47.7 nM for LRRK2-wild-type; LRRK2-G2019S; LRRK2-A2016T. JH-II-127 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 muM in a variety of cell types and is capable of inhibiting Ser935 phosphorylation in mouse brain following oral delivery of doses as low as 30 mg/kg. |
|---|
| Size | 5 mg, 25 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | [4- ( (5-chloro-4- (methylamino)-7H-pyrrolo[2; 3-d]pyrimidin-2-yl) amino)-3-methoxyphenyl) (morpholino) methanone] |
|---|
| Gene, Accession, CAS # | CAS: 1700693-08-8 |
|---|
| Catalog # | MBS845811 |
|---|
| Price | |
|---|
| Order / More Info | JH-II-127 from MYBIOSOURCE INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|