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| Product Name | COT, Unactive Recombinant protein |
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| Description | 30-397. MW: ~70 kDa. Recombinant human COT (30-397) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: COT is an oncogene that can activate both the MAP kinase and JNK kinase pathways. COT activates Itheta degree B kinases and induces the nuclear production of NF-theta degree B. C-terminal catalytic domain of KSR2 associates with COT and KSR2 can negatively regulates the kinase activity of COT in vitro. Co-transfection of KSR2 with |
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| Size | 0.02 mg, 0.05 mg |
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| Concentration | n/a |
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| Applications | Kinase Assay, Western Blot (WB) |
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| Other Names | [MAP3K8; EST; ESTF; TPL2; Tpl-2; c-COT; FLJ10486] |
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| Gene, Accession, CAS # | COT, Gene ID: 1326, Accession: NP_005195.2 |
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| Catalog # | MBS515331 |
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| Order / More Info | COT, Unactive Recombinant protein from MYBIOSOURCE INC. |
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| Product Specific References | 1. Channavajhala, P L. et al: Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling. J. Biol. Chem. 278: 47089-47097, 2003. 2. Rodra-guez C. et al: TRAF6 and Src kinase activity regulates Cot activation by IL-1. Cell Signal. 2006 Sep;18(9):1376-85. |
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