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| Product Name | Glucose Regulated Protein 94, Recombinant, Canine (Grp 94, gp96) |
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| Description | Purity ≥ 90% as determined by SDS-PAGE analysis. Glucose-regulated protein, Grp94 or gp96, is an abundant resident endoplasmic reticulum (ER) lumenal stress protein which together with cytosolic Hsp90 belong to the Hsp90 family of molecular chaperones. Grp94 and other resident soluble proteins of the ER such as members of the Ca(2+) binding protein subfamily (CaBP), CaBPI and CaBP2 as well as calreticulin possesses the COOH-terminal tetrapeptide Lys-Asp-Glu-Leu (KDEL) which is a sorting signal that is thought to lead to the retention of these proteins in the pre-Golgi compartments (1). Grp94 expression is upregulated by stress conditions such as glucose starvation and heat shock, which promote protein misfolding or unfolding (2). In addition to a homeostatic role in protein folding and assembly, Grp94 can function in the intracellular trafficking of peptides from the extracellular space to the MHC class I antigen processing pathway of antigen presentation cells (3,4). Grp94 and Hsp90 s |
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| Size | 25ug, 200ug |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P41148 |
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| Catalog # | G3057-41 |
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| Price | |
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| Order / More Info | Glucose Regulated Protein 94, Recombinant, Canine (Grp 94, gp96) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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