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| Product Name | Glucose Regulated Protein 78, Recombinant, Human (Grp78, BiP, KDEL) |
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| Description | Purity ≥ 90% pure as determined by SDS-PAGE analysis. GRP78 is a ubiquitously expressed, 78kD glucose-regulated protein, that is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein, and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5' nontranslated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed. GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis. Luo et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival. In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia, to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress |
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| Size | 50ug, 100ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | G3057-22C |
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| Order / More Info | Glucose Regulated Protein 78, Recombinant, Human (Grp78, BiP, KDEL) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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