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| Product Name | DAPT, gamma-Secretase Inhibitor IX |
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| Description | Purity ~95% (HPLC). Cell permeable. A potent inhibitor of g-secretase (IC50eQ5nM for total b-amyloid, IC50 = 200 nM for b-amyloid 1-42). It reduces Ab levels in vivo in plasma and cerebrospinal fluid in young and aged Tg2576 mice. Antagonizes Notch signaling through inhibition of Notch processing. DAPT treatment can influence hematopoietic cell fate decisions and enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independent of sonic hedgehog (shh) signaling. Formula: C23H26F2N2O4 Molecular Weight: 432.5 Primary Target: Abtotal Primary Target IC50: 115nM Secondary Target: Ab42 (IC50 = 200nM) |
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| Size | 5mg, 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | DAPT, gamma-Secretase Inhibitor IX (N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217312 |
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| Order / More Info | DAPT, gamma-Secretase Inhibitor IX from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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