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| Product Name | DAPT (GSI-IX, Secretase, gamma Inhibitor IX) |
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| Description | Cell permeable. A potent inhibitor of g-secretase (IC50 5nM for total b-amyloid, IC50 = 200 nM for b-amyloid 1-42). It reduces Ab levels in vivo in plasma and cerebrospinal fluid in young and aged Tg2576 mice. Antagonizes Notch signaling through inhibition of Notch processing. DAPT treatment can influence hematopoietic cell fate decisions and enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independent of sonic hedgehog (shh) signaling. Solubility: DMSO (~20mg/ml) Molecular Weight: 432.46 |
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| Size | 10mg, 50mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (S)-Tert-butyl 2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate; N-S-phenylglycine tert.butyl ester; GSI-IX; Secretase, gamma Inhibitor IX |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 255105 |
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| Order / More Info | DAPT (GSI-IX, Secretase, gamma Inhibitor IX) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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