| 产品详情 |
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| Product Name | DAPT (GSI-IX, Secretase, gamma Inhibitor IX) |
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| Description | Purity ~98% (HPLC). A cell-permeable dipeptide that inhibits y-secretase activity and suppresses Ab production (Ab total IC50=115nM; Ab42 IC50=200nM). Reported to be functionally active in both HEK293 cells overexpressing human APP751 and neuronal cultures, however, it does not affect the secretion of amyloid-b precursor protein (APP). Effective in acutely lowering Ab in APPV717F-transgenic mice. Also effective in inhibiting the production of an ~6kD C-terminal cleavage product (CTFg) in HEK293 cells stably transfected with the Swedish mutant, betaAPP695. Reported to reduce extracellular Ab plaques and intracellular Ab accumulation in 3xTgAD transgenic mice. |
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| Size | 5mg, 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (S)-Tert-butyl 2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate; N-S-phenylglycine tert.butyl ester; GSI-IX; Secretase, gamma Inhibitor IX |
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| Gene, Accession, CAS # | CAS: 208255-80-5 |
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| Catalog # | 29608 |
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| Price | |
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| Order / More Info | DAPT (GSI-IX, Secretase, gamma Inhibitor IX) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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