| 产品详情 |
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| Product Name | DARPP32 |
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| Description | Highly Purified. Peptide is used to block DARPP-32 Rabbit mAb reactivity in immunohistochemistry protocols. DARPP-32 (dopamine and cyclic AMPregulated phosphoprotein, relative molecular mass 32,000) is a cytosolic protein highly enriched in medium-sized spiny neurons of the neostriatum (1). It is a bifunctional signaling molecule that controls serine/threonine kinase and serine/ threonine phosphatase activity (2). Dopamine stimulates phosphorylation of DARPP-32 through D1 receptors and activation of PKA. PKA phosphorylation of DARPP-32 at Thr34 converts it into an inhibitor of protein phosphatase 1 (1). DARPP-32 is converted into an inhibitor of PKA when phosphorylated at Thr75 by cyclin-dependent kinase 5 (CDK5) (2). Mice containing a targeted deletion of the DARPP-32 gene exhibit an altered biochemical, electrophysiological and behavioral phenotype (3). Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry. The peptide blocks DARPP- |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | IHC |
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| Other Names | DARPP32 (Dopamine and cAMP-regulated Phosphoprotein, Protein phosphatase 1 regulatory subunit 1B, PP1R1B) Blocking Peptide |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | D1075-08 |
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| Price | |
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| Order / More Info | DARPP32 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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