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| Product Name | DARPP 32, Recombinant, Human, His-Tag |
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| Description | Purity ~90% by SDS-PAGE. The Recombinant DARPP-32 His fusion protein preparation shows two bands of 38kD and 26kD, the latter representing a form lacking ~10-12kD from the carboxy terminus. Both bands are excellent substrates for phosphorylation. DARPP-32 (dopamine and cyclic AMP regulated phosphoprotein, relative MR 32kD) is a cytosolic protein highly enriched in mediumsized spiny neurons of the neostriatum (1). Dopamine stimulates phosphorylation of DARPP-32 through D1 receptors and activation of PKA. PKA phosphorylation of DARPP-32 at threonine 34 converts it into an inhibitor of protein phosphatase 1 (1). DARPP-32 is converted into an inhibitor of PKA when phosphorylated at threonine 75 by cyclin-dependent kinase 5 (cdk5) (2). Mice containing a targeted deletion of the DARPP-32 gene exhibit an altered biochemical, electrophysiological and behavioral phenotype (3). DARPP-32 is a bifunctional signal transduction molecule that controls serine/threonine kinase and serine/threonine phos |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | DARPP 32, Recombinant, Human, His-Tag (Dopamine and cAMP-regulated Phosphoprotein, Protein phosphatase 1 regulatory subunit 1B, PP1R1B) |
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| Gene, Accession, CAS # | SwissProt: Q9UD71 |
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| Catalog # | D1075 |
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| Price | |
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| Order / More Info | DARPP 32, Recombinant, Human, His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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