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| Product Name | PODXL, Recombinant, Human, aa32-458, His-Tag (Podocalyxin) |
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| Description | Purity ~90% (SDS-PAGE). Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. Source: Recombinant protein corresponding to aa32-458 from human PODXL, fused to |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | GCTM-2 antigen, Gp200 Podocalyxin-like protein 1,PC, PCLP-1 |
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| Gene, Accession, CAS # | SwissProt: O00592 |
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| Catalog # | 374778 |
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| Order / More Info | PODXL, Recombinant, Human, aa32-458, His-Tag (Podocalyxin) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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