| 产品详情 |
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| Product Name | 17b-Hydroxysteroid Dehydrogenase Type-3 Inhibitor |
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| Description | Purity ~97% (HPLC). A cell-permeable benzylidine-thioxothiazolidinone compound that blocks the steroidogenesis of testosterone by directly inhibiting 17b-HSD3- (17b-hydroxysteroid dehydrogenase type 3) catalyzed, NADPH-dependent, reduction of delta4-dione C17 ketone in a delta4-dione- (4-androstene-3,17-dione) competitive, highly potent (IC50=0.6, 6.0, and 40nM, respectively, against momoset, human, and mouse 17b-HSD3 activity in testes homogenate), and selective manner, displaying no activity against 17b-HSD1 and 17b-HSD2 activity. Poor pharmacokinetic properties limit its use to culture treatments and cell-free assays only. Formula: C17H12BrNO3S2 Molecular Weight: 422.3 Solubility: DMSO (50mg/ml, pinkish solution) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 17b-Hydroxysteroid Dehydrogenase Type-3 Inhibitor (17b-HSD3 Inhibitor, 5-(3-Bromo-4-hydroxybenzylidene)-3-(4-methoxyphenyl)-2-thioxothiazolidin-4-one) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217117 |
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| Order / More Info | 17b-Hydroxysteroid Dehydrogenase Type-3 Inhibitor from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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