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| Product Name | WM983B Non-Viable Cell Pellet (2 x 10^6 cells) |
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| Description | Non-viable cell pellet was generated from cell line WM983B. WM983B is a human metastatic melanoma cell line that was established from an inguinal node metastatic site in a 54-year-old male patient. The subject displayed malignant melanoma of polypoid type, level IV with a tumor thickness of 2.5 cm. MW983B line contains the BRAF V600E mutation that causes increased signaling via the extracellular signal-regulated MAPK/ERK kinase pathways to enhance proliferation. WM983B is wild type for PTEN, N-ras, c-KIT, and CDK4. This cell line was derived from the same patient as the cell lines WM983A, WM983B BR, and WM983C. WM983B cells produce xenograft tumors when injected into immunocompromised mice. |
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| Size | 2 mg |
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| Concentration | 2.0 million cells |
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| Applications | Frozen non-viable cell pellets can be used for in vitro experiments such as Western blotting and other immunoassays, genomic DNA isolation, STR profiling, and RNA isolation. |
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| Other Names | Human Melanoma, patient derived tumor, tumor models, skin cancer, xenograft |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | WM983B-03-0002 |
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| Order / More Info | WM983B Non-Viable Cell Pellet (2 x 10^6 cells) from ROCKLAND IMMUNOCHEMICALS INC. |
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| Product Specific References | Jelena Grahovac, Dorothea Becker, and Alan Wells. Melanoma cell invasiveness is promoted at least in part by the Epidermal Growth Factor-like repeats of Tenascin-C. J Invest Dermatol. (2013) 133: 210-220. doi: 10.1038/jid.2012.269 |
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