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| Antigenic Specificity | Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (Extracellular Domain) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | rat, mouse |
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| Isotype | n/a |
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| Format | serum |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (IHC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Function: Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 which bridges NTRK1 to NGFR. Interacts with NGFR and ARMS. Can form a ternary complex with NGFR and ARMS and this complex is affected by the expression levels of ARMS. An increase in ARMS expression leads to a decreased association of NGFR and NTRK1.Subcellular location: Cell membrane, Single-pass type I membrane protein. Note: Endocytosed to the endosomes upon treatment of cells with NGF.Tissue specificity: Isoform Trka-II is primarily expressed in neuronal cells, isoform Trka-I is found in non-neuronal tissues. Also known as: High affinity nerve growth factor receptor, NTRK1, p140-TrkA, Trk-A, Neurotrophic tyrosine kinase receptor type 1, Slow nerve growth factor receptor. |
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| Immunogen | A synthetic peptide from the extracellular domain of rat TrkA conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse. |
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| Other Names | trk|trka|TRKA|MTC|TRK|TRK1|Trk-A|p140-TrkA|C80751|Tkr|TrkA|Trk|CTRKA|trkA|CAPM1|CFTD|NEM1|OK/SW-cl.5|TM-5|TM3|TM30|TM30nm|TM5|TPMsk3|hscp30 |
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| Gene, Accession # | Gene ID: 18211,59109 |
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| Catalog # | ABIN351064 |
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| Order / More Info | Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (Extracellular Domain) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 15167895, 8325889, 15378608, 12471037, 11150334, 1312719, 9856458, 11244088 |
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