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| Product Name | Epoxomicin (Antibiotic BU 4061T) |
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| Description | Purity ≥97% (NMR). Antibiotic. Potent anticancer compound. Cell permeable, potent, selective and irreversible 20S proteasome inhibitor. Predominantly inhibits the chymotrypsin-like (CTRL) activity of the proteasome. Exhibits lower level inhibition of proteasome trypsin-like and caspase-like activitives (100 and 1,000-fold slower rates respectively). Anti-inflammatory. Antimicrobial and antimalarial. Anti-parasitic. Stimulates bone formation by inhibiting osteoblast proteasome activity. Induces Parkinson's-like symptoms in rats. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems. Blockade of UPS by Epoxomicin activates autophagy. |
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| Size | 50ug, 100ug, 250ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | CAS: 134381-21-8 |
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| Catalog # | 226810 |
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| Order / More Info | Epoxomicin (Antibiotic BU 4061T) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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