| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | Siglec H |
|---|
| Clone | 440c |
|---|
| Host Species | Rat |
|---|
| Reactive Species | mouse |
|---|
| Isotype | n/a |
|---|
| Format | unconjugated |
|---|
| Size | 100 µg |
|---|
| Concentration | n/a |
|---|
| Applications | Immunohistochemistry (Frozen Sections) (IHC (fro)),Flow Cytometry (FACS),Inhibition Assay (InhA) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | The monoclonal antibody 440c reacts with Siglec-H, a cell-surface receptor molecule selectively expressed on murine natural interferon producing cells (IPC), also called mouse plasmacytoid dendritic cells (pDC). Siglec H is unique among Sialic acid-binding Ig-like lectins (Siglecs) proteins because it associates with the adaptor protein DAP12. DAP12 recognize certain viruses and CpG-DNA through TLR9, resulting in secretion of IFN-alpha, IL-12 and proinflammatory chemokines. Together these cytokines and chemokines recruite and activate NK cells and T cells as well as modulating the antigen presenting function of dendritic cells (DC). IPC themselves also function as antigen presenting cells that expand memory T cells and induce Th1 differentiation. Therefore IPC may provide a first line of host defense against viral infections by activating both innate and adaptive responses in vivo. The monoclonal antibody 440c exclusively recognizes mouse Siglec-H in all lymphoid organs under both normal and inflammatory conditions. Siglec-H is normal present in the T cell zone of lymph nodes and spleen. Incubation of IPC with antibody 440c in vitro or administration of antibody 440c in vivo reduces secretion of IFN-alpha in response to CpG DNA without causing IPC depletion. |
|---|
| Immunogen | n/a |
|---|
| Other Names | 6430529G09Rik|Siglec-H |
|---|
| Gene, Accession # | Gene ID: 233274 |
|---|
| Catalog # | ABIN2191824 |
|---|
| Price | |
|---|
| Order / More Info | Siglec H Antibody from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | PubMed: 16293595, 14695235 |
|---|
| 产品资料 |
|
|