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| Product Name | Interferon-alpha/beta Receptor 1, Recombinant, Human, aa26-436 (IFNAR1, IFN-alpha/beta R1) |
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| Description | Purity ~95% (SDS-PAGE). Interferon alpha/beta receptor 1 (IFNalpha/beta R1), also known as IFNAR1, is a 100130kD member of the class II cytokine receptor family of proteins. These proteins form heterodimeric receptor complexes that mediate class II cytokine signals. Subunits of the different receptor complexes are shared and serve multiple functions (1). IFNalpha/beta R1, in association with IFNalpha/beta R2, is required for propagating antimicrobial signal transduction triggered by the type 1 interferons such as IFNalpha and IFNbeta (2, 3). Mature human IFNalpha/beta R1 consists of a 409 aa extracellular domain (ECD), a 21 aa transmembrane segment, and a 100 aa cytoplasmic domain (4). The ECD contains three tandem fibronectin type III repeats and is extensively glycosylated. Within the ECD, human IFNalpha/beta R1 shares 47% and 50% aa identity with mouse and rat IFNalpha/beta R1, respectively. Alternative splicing generates two additional isoforms that lack the transmembra |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P17181 |
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| Catalog # | 145709 |
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| Order / More Info | Interferon-alpha/beta Receptor 1, Recombinant, Human, aa26-436 (IFNAR1, IFN-alpha/beta R1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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