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| Product Name | D-myo-Inositol-3,4,5-triphosphate (sodium salt) |
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| Description | Purity >98%. D-myo -Inositol-1,4,5-triphosphate (Ins(1,4,5)-P3 ) is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate. Binding of Ins(1,4,5)-P3 to its receptor on the endoplasmic reticulum in opening of the calcium channels and an increase in intracellular calcium. D-myo -Inositol-3,4,5-triphosphate (Ins(3,4,5)-P3 ) is a structural analog of Ins(1,4,5)-P3 and a member of the inositol phosphate (InsP) cell signaling family of molecules. D-myo Ins(3,4,5)-P3 is 200-fold less potent than D-myo Ins(1,4,5)-P3 at initiating Ca+ + release when injected into Xenopus oocytes. Ins(1,4,5)-P3 binds to Type 1, 2, and 3 subtypes of the rat recombinant IP3 receptor with Ki values of less than 25 nM, whereas Ins(3,4,5)-P3 exhibits significantly lower affinity with Ki values of 3-11 µM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | D-myo -inositol-3,4,5-tris (hydrogen phosphate), trisodium salt, 3,4,5-IP4, Ins(3,4,5)-P3 |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | LS-H7543 |
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| Order / More Info | D-myo-Inositol-3,4,5-triphosphate (sodium salt) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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