| 产品详情 |
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| Product Name | AI-1 |
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| Description | Purity >98% (NMR, HPLC). AI-1 is a novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1 by AI-1 disrupts the ability of Keap1 to searve as an adaptor for Cul3-Keap1 ubiquitin ligase complex, thereby stabilizing and inducing transcriptional activation of Nrf2. AI-1 is a useful pharmacological tool for probing the involvement of Nrf2 in cellular physiology. Cell permeable. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-Chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester |
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| Gene, Accession, CAS # | CAS: 75483-04-4 |
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| Catalog # | LS-H14589 |
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| Order / More Info | AI-1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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