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| Product Name | CHIR 98014 |
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| Description | Highly Purified (~98%). Synonyms: CHIR98014, CHIR-98014 Chemical Name: 6-N-[2-[[4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethyl]-3-nitrop yridine-2,6-diamine Molecular Formula: C20 H17 Cl Molecular Weight: 486.3 CAS Number: 556813-39-9 Purity: ≥98% Applications: FA Appearance: Crystalline solid Description: CHIR 98014 is a potent and reversible inhibitor of Glycogen Synthase Kinase 3 (GSK3), inhibiting both the alpha (IC50: 0.65 nM) and beta (IC50: 0.58 nM) isoforms. GSK3 functions by phosphorylating a serine or threonine residue on its target substrate and is part of the Wnt pathway that signals the cell to divide and proliferate. CHIR 98014 activates glycogen synthase in cells to improve glucose disposal and to reduce tau phosphorylation in neurons. It is reported to stimulate vascular cell differentiation of hPSC and enhances the transformation of vascular smooth muscle cells into osteogenic-like cells under high phosphate conditions. Storage: Soluble in organic solvents such as DMSO. |
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| Size | 5mg, 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-N-[2-[[4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethyl]-3-nitropyridine-2,6-diamine, CHIR98014, CHIR-98014 |
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| Gene, Accession, CAS # | CAS: 556813-39-9 |
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| Catalog # | 366874 |
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| Order / More Info | CHIR 98014 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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