| 产品详情 |
| Edit |   |
|---|
| Product Name | PRL-3 Inhibitor (BR-1, P0108, Phosphatase of Regenerating Liver 3 Inhibitor, PTP4A3 Inhibitor) |
|---|
| Description | Highly Purified (~98%). Phosphatase of regenerating liver 3 (PRL-3, also known as PTP4A3) plays critical roles in cell proliferation, motility, and invasion, and thus contributes to cancer metastasis. PRL-3 inhibitor is a cell-permeable benzylidene rhodamine that inhibits PRL-3 (IC50=900nM for human PRL-3 in vitro), with minimal activity against other phosphatases. It reduces the invasion of mouse melanoma B16F10 cells in a cell-based assay. PRL-3 inhibitor has been used to elucidate the actions of this enzyme, demonstrating that it dephosphorylates Tyr783 on integrin beta1 and modulates VEGF-mediated endothelial cell migration. It dose-dependently inhibits the growth and triggers apoptosis in cancer cell lines. CAS Number: 893449-38-2 Molecular Formula: C17H11Br2NO2S2 Solubility: Organic solvents DMSO and dimethyl formamide (~16mg/ml), which should be purged with an inert gas. Sparingly soluble in aqueous buffers. Molecular Weight: 485.2 Lambda max: 273, 384nm |
|---|
| Size | 1mg, 5mg, 10mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 5-[[5-bromo-2-[(2-bromophenyl) methoxy]phenyl]methylene]-2- thioxo-4-thiazolidinone |
|---|
| Gene, Accession, CAS # | CAS: 893449-38-2 |
|---|
| Catalog # | 349626 |
|---|
| Price | |
|---|
| Order / More Info | PRL-3 Inhibitor (BR-1, P0108, Phosphatase of Regenerating Liver 3 Inhibitor, PTP4A3 Inhibitor) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|