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| Product Name | Bufalin |
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| Description | Purity >98%. Bufalin is a cardiotonic steroid first isolated from toad venom and used in traditional Asian medicine. It inhibits the Na+ /K+ -ATPase transporter (Kd s = 42, 45, and 40 nM for the Alpha1, Alpha2, and Alpha3 subunits, respectively). Intravenously administered bufalin is cleared rapidly, with a plasma half-life of 25 minutes in dogs and rats. Bufalin inhibits steroid receptor coactivator 1 (SRC-1) and SRC-3 at doses as low as 5 nM, promotes the degradation of SRC-3 protein, and inhibits cancer cell growth both in vitro and in vivo . It can also impact the action and expression of several other proteins and kinases as well as induce apoptosis in various cancer cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (3Beta,5Beta)-3,14-dihydroxy-bufa-20,22-dienolide, NSC 89595 |
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| Gene, Accession, CAS # | CAS: 465-21-4 |
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| Catalog # | LS-H6918 |
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| Price | |
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| Order / More Info | Bufalin from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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