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| Product Name | PRKC1, Recombinant, Human, Active (PKC iota, Protein Kinase C iota Type) |
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| Description | Purity ~90% (SDS-PAGE). PKC iota is a member of the protein kinase C family of serine-threonine kinases. The amino acid sequence of PKC iota showed greatest homology to PKC zeta, with 72% identity overall rising to 84% in the catalytic domain. In contrast, the homology of PKC iota to the other isoforms is less pronounced, with <53% identity even in the highly conserved catalytic region. PKC iota transcript is present predominantly in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets. PKC iota is stimulated by tumor necrosis factor alpha (TNF-a) and is required for the activation of NF-kB by this cytokine. Cell transfections with a PKC iota dominant negative mutant abolished TNF-a-induced NFkB-dependent transcription. PKC iota can modify vulnerability of neural cells to apoptosis induced by amyloid beta-peptide (ABP), a cytotoxic peptide linked to neuronal degeneration in Alzheimer's disease. Associated with the increased resistance to apopto |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | c ι, Active PKC ι, PKC ι, PKC i, humanPKC ι, human PKC i, Active kinases, recombinant PKC i, Recombinant PKC ι, recombinant PKC, Kinase activity assay, protein kinase |
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| Gene, Accession, CAS # | PRKC1, Gene ID: 5584, Accession: NM_002740 |
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| Catalog # | 220182 |
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| Order / More Info | PRKC1, Recombinant, Human, Active (PKC iota, Protein Kinase C iota Type) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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