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| Product Name | NFNB, Recombinant, Bacterial, His-tag |
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| Description | Purity ~95% (SDS-PAGE). NFNB, also known as NFSB, shows the ability to reduce quinines. This protein is an enzyme for activating prodrugs in antibody directed enzyme prodrug therapy. It also capable of reducing nitrofurazone, quinones and the anti-tumor agent CB1954 (5-(aziridin-1-yl)-2, 4-dinitrobenzamide). The reduction of CB1954 results in the generation of cytotoxic species. Recombinant E. coli NFNB protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. Source: Recombinant protein corresponding to aa1-217 and 237aa of bacterial NFNB, fused to HIs-tag at N-terminal expressed in E. coli. Molecular Weight: ~26kD Specific Activity: >2units/ml Unit Definition: One unit will oxidize 1.0umole of b-NADH to b-NAD with 6.7-Dimethyldihydropterine (quinonoid isomer) as the non-nucleotide substrate per minute at pH 7.2 at 25°C AA |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | NFNB, Recombinant, Bacterial, His-Tag (Dihydropteridine Reductase, NAD(P)H-Dependent, Oxygen-Insensitive, DprA, NfsB, NfsI, Ntr) |
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| Gene, Accession, CAS # | NFNB, Gene ID: 4493867 |
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| Catalog # | 301250 |
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| Order / More Info | NFNB, Recombinant, Bacterial, His-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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