| 产品详情 |
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| Product Name | Nodinitib-1 |
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| Description | Purity ~99% (HPLC). A cell-permeable aminobenzimidazole compound that acts as a potent, specific and reversible inhibitor of NOD1 (Nucleotide-binding Oligomerization Domain 1; NLRC1, CARD4, or CLR7.1)-induced NF-kB activation (IC50=0.56uM, >20, and >20 by NOD1 ligand, NOD2 ligand and TNFa in HEK293T-NF-kB-luciferase cells, respectively). Shown to block phosphorylation and degradation of IkBa and MAPK signaling (5uM in HCT-116 cells) with no effect on Akt pathway. Suggested to directly interact with NOD1, alter the conformation and suppress RIP2 trafficking, a NOD1-binding partner required for NF-kB induction. Formula: C14H13N3O2S Molecular Weight: 287.3 Solubility: DMSO (50mg/ml, clear, colorless solution) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Nodinitib-1 (CID-1088438, ML130, 1-[(4-Methylphenyl)sulfonyl]-1H-benzimidazol-2-amine, 1-(Toluene-4-sulfonyl)-1H-benzimidazol-2-ylamine, NOD1 Signaling Inhibitor, Nucleotide-binding Oligomerization Domain 1 Signaling Inhibitor) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217596 |
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| Price | |
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| Order / More Info | Nodinitib-1 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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