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| Product Name | TNF-alpha, Recombinant, Human (Tumor Necrosis Factor-alpha) |
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| Description | Purity ~98% (RP-HPLC, SDS-PAGE). Tumor necrosis factor is a cytokine involved in systemic inflammation and is a member of a group of cytokines that all stimulate the acute phase reaction. TNF is mainly secreted by macrophages. TNF causes apoptotic cell death, cellular proliferation, differentiation, inflammation, tumorigenesis and viral replication, TNF is also involved in lipid metabolism, and coagulation. TNF's primary role is in the regulation of immune cells. Dysregulation and, in particular, overproduction of TNF have been implicated in a variety of human diseases- autoimmune diseases, insulin resistance, and cancer. Source: Recombinant protein corresponding to human TNF-alpha, a single, non-glycosylated, polypeptide chain containing 158aa, expressed in E. coli. Molecular Weight: ~17.5kD Biological Activity: The ED50, as determined by the cytolysis of murine L929 cells in the presence of Actinomycin D, is <0.05ng/ml, corresponding to a specific activity of 2x10e7IU/mg. AA Sequence |
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| Size | 10ug, 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 299544 |
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| Order / More Info | TNF-alpha, Recombinant, Human (Tumor Necrosis Factor-alpha) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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