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| Product Name | TNF-a, mouse, BioAssay™ ELISA Kit (Tumor Necrosis Factor alpha) |
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| Description | Tumor Necrosis Factor alpha (TNF-a) is a multifunctional proinflammatory cytokine, mainly secreted by activated macrophages. The cytokine was named for its remarkable ability to cause hemorrhagic necrosis of tumors in mice. It is implicated with a variety of biological procedures including systemic inflammation, cell proliferation, apoptosis, lipid metabolism, and coagulation. It is well documented that TNF-a functions through its receptors, TNFR1 (p55) and TNFR2 (p75). TNF-a plays an important role in the immune response to bacterial, and certain fungal, viral, parasitic invasions, in tissue remodeling, autoimmune-diseases and the necrosis of specific tumors. The pleiotropic effect of TNF-a regulation is attributed to its ability to trigger multiple signaling pathways simultaneously. TNF-a hyper-expression in response to the components of some bacteria such as LPS can cause life threatening septic shock. Recombinant TNF-a, in combination with chemotherapy, has been applied for synergi |
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| Size | 96 tests |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 216058 |
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| Order / More Info | TNF-a, mouse, BioAssay™ ELISA Kit (Tumor Necrosis Factor alpha) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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