| 产品详情 |
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| Product Name | 1-NA-PP1 |
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| Description | Purity >98%. 1-NA-PP1 is a reversible, cell-permeable inhibitor of Src-family tyrosine kinases that have been mutated, by a single base substitution, to become 'analog sensitive' (as), as compared to the wild-type kinase. 1-NA-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 1.5 nM versus 1.0 µM, respectively). The homologous mutation in other kinases generated similar analog sensitivity (e.g., IC50 = 1.5 nM for c-Fyn-as1 versus 0.6 µM for c-Fyn; 7.0 nM for c-Abl-as2 versus 0.6 µM for c-Abl; 15 nM for Cdk2-as1 versus 18 µM for Cdk2). This approach has been used to elucidate functions of several kinases in both mammalian and yeast systems. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, 1-Naphthyl-PP1, PP1 Analog |
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| Gene, Accession, CAS # | CAS: 221243-82-9 |
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| Catalog # | LS-H5901 |
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| Order / More Info | 1-NA-PP1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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