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| Product Name | (E)-C-HDMAPP (ammonium salt) |
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| Description | Purity >95%. Synthetic and natural alkyl phosphates, also known as phosphoantigens, stimulate the proliferation of GammaDelta-T lymphocytes. Isopentenyl pyrophosphate, and related derivatives including (E)-hydroxy-dimethyl-allyl pyrophosphate ((E)-HDMAPP), are particularly effective activators of GammaDelta-T cells. 3 (E)-C-HDMAPP is the pyrophosphonate form of (E)-HDMAPP. The pyrophosphonate moiety in (E)-C-HDMAPP is much less susceptible to chemical or enzymatic hydrolysis than its pyrophosphate counterpart. As a result, (E)-C-HDMAPP is much more stable in solution and in vascular circulation. (E)-C-HDMAPP possesses comparable activity to (E)-HDMAPP, which is the most potent of the isoprenoid phosphoantigens. (E)-C-HDMAPP stimulates the synthesis of tumor necrosis factor (TNF-Alpha) by GammaDelta-T lymphocytes with an IC50 value of 0.91 nM. (E)-C-HDMAPP also significantly increases the number of circulating GammaDelta-T cells in vivo, in cynomolgus monkeys. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | P'-[(3E)-5-hydroxy-4-methyl-3-penten-1-yl]-isohypophosphoric acid, triammonium salt, (E)-5-hydroxy-4-methylpent-3-enyl pyrophosphate |
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| Gene, Accession, CAS # | CAS: 933030-60-5 |
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| Catalog # | LS-H5620 |
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| Order / More Info | (E)-C-HDMAPP (ammonium salt) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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