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| Product Name | Parathyroid Hormone, Recombinant, Human, aa1-84 (Parathyrin, PTH, Parathormone) |
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| Description | Purity ~95% (RP-HPLC, SDS-PAGE). Parathyroid hormone (PTH), or parathormone, is secreted by the parathyroid glands as a polypeptide containing 84aa. It acts to increase the concentration of calciumin the blood, whereas calcitonin (a hormone produced by the parafollicular cells of the thyroid gland) acts to decrease calcium concentration. PTH acts to increase the concentration of calcium in the blood by acting upon parathyroid hormone receptorin three parts of the body: In the bones- It enhances the release of calcium from the large reservoir contained in the bones. Bone resorptionis the normal destruction of bone by osteoclasts, which are indirectly stimulated by PTH. Stimulation is indirect since osteoclasts do not have a receptor for PTH; rather, PTH binds to osteoblasts, the cells responsible for creating bone. Binding stimulates osteoblasts to increase their expression of RANKL, which can bind to osteoclast precursors containing RANK, a receptor for RANKL. The binding of RANKL to R |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 209134 |
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| Order / More Info | Parathyroid Hormone, Recombinant, Human, aa1-84 (Parathyrin, PTH, Parathormone) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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