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| Product Name | Heme oxygenase, Recombinant, Human, aa2-291, His-Tag (HO-2, HMOX2) |
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| Description | Purity ~95% (SDS-PAGE). Heme oxygenase (HO) is the rate limiting enzyme in heme catabolism (1). It cleaves heme to biliverdin, carbon monoxide, and iron; biliverdin is subsequently converted by biliverdin reductase to bilirubin. The mechanism of HO is unique in that heme serves as both the substrate of the enzyme and as the prosthetic group for the activation of iron-bound O2. HO activity is highest in spleen where senescent erythrocytes are sequestered and destroyed. Two isoforms, HO-1 and HO-2, are expressed in most tissues. HO-1 is an inducible enzyme in response to heavy metals, oxidative stress, cytokines, and many drugs (2). HO-2 is constitutively expressed in the brain and testes. HO-1 is expressed mainly in spleen, liver, and kidney. In addition to its activity in the heme degradation pathway, erves as an oxygen sensor through its heme regulating motifs, which have the core sequence of Cys-Pro (3). Source: Recombinant protein corresponding to aa2-291 from human HO-2/HMOX2, fuse |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P30519 |
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| Catalog # | 145800 |
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| Order / More Info | Heme oxygenase, Recombinant, Human, aa2-291, His-Tag (HO-2, HMOX2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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