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| Product Name | Heme Oxygenase 1, Recombinant, Rat (HO-1, HSP32, Heat Shock Protein 32) |
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| Description | Purity ≥90% (SDS-PAGE). Heme oxygenase is the rate-limiting microsomal enzyme in the heme degradative pathway. Heme oxygenase catalyzes the NADPH, O2 and cytochrome P450 reductase dependent oxidation of heme to form equimolar biliverdin, carbon monoxide, a putative neurotransmitter, and iron. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator; biliverdin and its product bilirubin are potent antioxidants; free' iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferrin receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'-UTRs of the mRNAs. To date, 3 forms of heme oxygenases (HO1-3) have been identified. HO-1 or Hsp-32 (EC 1.14.99.3; mouse/rat 289 aa; human 288 aa, chromosome 22; ~88% homology between the spec |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | H1847-67 |
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| Order / More Info | Heme Oxygenase 1, Recombinant, Rat (HO-1, HSP32, Heat Shock Protein 32) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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