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| Product Name | Hh Signaling Antagonist XII, MRT-83 |
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| Description | Purity ~98% (HPLC). A cell-permeable acylguanidine compound that is shown to block Hh signaling and act as a potent, reversible and high-affinity Smo (Smoothened) antagonist. Displays 20-60 -fold greater potency than Cyclopamine and competitively inhibits bodipy-cyclopamine binding to Smo (IC50 = 4.6 and 14nM in HEK293-hSMO and HEK293-mSMO cells, respectively). Represses ShhN (N-myristoylated Shh) signaling (IC50=15nM for Gli-dependent luciferase activity in Shh-light2 cells) and SAG- induced C3H10T1/2 cell differentiation (IC50=10nM in an alkaline phosphatase activity assay). Inhibits ShhN (3nM) and SAG (10nM)-mediated proliferation of rat cerebellar granule cell precursors (IC50 ~3 and 6nM, respectively). Formula: C31H30N4O5 Molecular Weight: 538.6 Solubility: DMSO (100mg/ml) |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Hh Signaling Antagonist XII, MRT-83 (N-(2-Methyl-5-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)-(1,1'-biphenyl)-4-carboxamide) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217422 |
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| Order / More Info | Hh Signaling Antagonist XII, MRT-83 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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