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| Product Name | HNRNPD, Recombinant, Human, aa18-355, GST-Tag (Heterogeneous Nuclear Ribonucleoprotein D0) |
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| Description | Purity ~90% (SDS-PAGE). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the Cytoplasmic domain deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulati |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | AU-rich element RNA-binding protein 1 |
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| Gene, Accession, CAS # | SwissProt: Q14103 |
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| Catalog # | 373667 |
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| Order / More Info | HNRNPD, Recombinant, Human, aa18-355, GST-Tag (Heterogeneous Nuclear Ribonucleoprotein D0) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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