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| Product Name | SOCS1, Recombinant, Human, aa1-211, His-Tag (Suppressor of Cytokine Signaling 1) |
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| Description | Purity ~90% (SDS-PAGE). SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. Source: Recombinant protein corresponding to aa1-211 from human SOCS1, fused to His-Tag at N-terminal, expressed in Yeast. Molecular Weight: ~25.6kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | JAK-binding protein, JABSTAT-induced STAT inhibitor 1, SSI-1 Tec-interacting protein 3, TIP-3 |
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| Gene, Accession, CAS # | SwissProt: O15524 |
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| Catalog # | 375365 |
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| Order / More Info | SOCS1, Recombinant, Human, aa1-211, His-Tag (Suppressor of Cytokine Signaling 1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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