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| Product Name | 7-alpha, 25-dihydroxycholesterol (EBI2 agonist, EBI2 Activator, GPR183 Activator, 7alpha,25-OHC) |
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| Description | Purity ~98% (HPLC). A highly potent and specific oxysterol EBI2 (GPR183) agonist with a kd of 450pM in a saturation binding analysis, and activates EBI2 (EC50=140pM compared with 2.1nM for its enantiomer 7b,25-OHC) in a GTP-gamma assay. Dose-dependenty suppresses forskolin-induced cAMP accumulation in EBI2-expressing SK-N-MC/CRE-beta galactosidase cell line with an IC50 of 2nM, but not in control cells. Stimulates migration of LPS-activated spleen B cells and T cells in a dose-dependent manner. In addition, pharmacological inhibition of its biosynthesis in vivo by Clotrimazole, a CYP7B1inhibitor promotes the migration of adoptively transferred pre-activated B cells to the T/B boundary, mimicking the phenotype of pre-activated B cells from EBI2-deficient mice. Formula: C27H46O3 Solubility: DMSO Molar Mass: 418.3 |
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| Size | 1mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217131 |
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| Order / More Info | 7-alpha, 25-dihydroxycholesterol (EBI2 agonist, EBI2 Activator, GPR183 Activator, 7alpha,25-OHC) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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