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| Product Name | DST, Recombinant, Human, aa1-195, His-Tag (Dystonin) |
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| Description | Purity ~90% (SDS-PAGE). Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Isoform 3: plays a structural role in the assembly of hidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity. Isoform 6: required for bundling actin filaments around the nucleus.Isoform 7: regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Source: Recombinant protein corresponding to aa1-195 from human DST, fused to His-Tag at N-terminal, expressed in Yeast. Mol |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 230kD bullous pemphigoid antigen, 230/240kD bullous pemphigoid antigen, Bullous pemphigoid antigen 1, BPA, Bullous pemphigoid antigen Dystonia musculorum protein Hemidesmosomal plaque protein |
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| Gene, Accession, CAS # | SwissProt: Q03001 |
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| Catalog # | 373103 |
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| Order / More Info | DST, Recombinant, Human, aa1-195, His-Tag (Dystonin) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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