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| Product Name | Insulin Receptor Substrate 1, pS616 Phospho/Non-phospho Control Peptides (IRS-1) |
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| Description | Purity ~90% by HPLC and MS analysis. Insulin Receptor Substrate-1 (IRS-1) is a major endogenous substrate for the insulin receptor and IGF-1R tyrosine kinase. Although IRS-1 is constitutively phosphorylated on serine and threonine, it is tyrosine-phosphorylated only after stimulation by insulin. The tyrosine phosphorylated IRS-1 serves as the major agent of insulin receptor-mediated signal transduction by being bound by cytoplasmic signaling proteins containing SH2 domains. Numerous SH2-containing signaling proteins (e.g., Grb2, SH-PTP2/SYP, PI-3-Kinase, and NCK) are known to preferentially bind to distinct tyrosine phosphorylation sites on IRS-1. Kit Components: I7661-27A1: IRS-1 Positive Control Peptide (Phosphorlyated) MW: 1573D; 1x100ug I7661-27A2: IRS-1 Negative Control Peptide (Non Phosphorlyated) MW: 1492; 1x100ug |
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| Size | 1mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | I7661-27A |
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| Order / More Info | Insulin Receptor Substrate 1, pS616 Phospho/Non-phospho Control Peptides (IRS-1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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