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| Product Name | Insulysin, Recombinant, Rat, 5-His-Tag |
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| Description | Purity ~95% (SDS-PAGE) Endotoxin: ≤1EU/1ug (LAL). Insulysin, or insulin-degrading enzyme (IDE), is a zinc metallopeptidase of the inverzincin family. IDE is primarily located in the cytosol, but has been detected as a secreted enzyme and associated with the plasma membrane as well. The enzyme is expressed in many tissues, with the highest levels in liver, kidney, brain, and testis. IDE hydrolyzes a variety of regulatory peptides, including insulin, glucagon, atrial natriuretic factor, and transforming growth factor-a in vitro. In addition, IDE has been shown to degrade the amyloid b (Ab) peptide, which polymerizes into the plaques associated with Alzheimer's disease. Deficiencies in IDE activity may contribute to the pathogenesis of type 2 diabetes mellitus (DM2) and Alzheimer's disease. The IDE region of human chromosome 10q has been genetically linked to DM2. When the IDE gene was specifically disrupted in mice, IDE -/- animals developed hyperinsulinemia and glucose intolerance, char |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Insulysin, Recombinant, Rat, 5-His-Tag (IDE, insulin-degrading enzyme, FLJ35968, Insulinase, Insulin-degrading Enzyme, Insulin Protease) |
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| Gene, Accession, CAS # | Gene ID: 25700, SwissProt: P35559 |
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| Catalog # | I8601-04 |
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| Order / More Info | Insulysin, Recombinant, Rat, 5-His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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