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| Product Name | Recombinant Conus striatus Con-ikot-ikot |
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| Description | 38-123aa; Full Length. MW: 13.5kD. Purity >90% as determined by SDS-PAGE. Potently and selectively blocks the desensitization of ionotropic glutamate AMPA receptor (GRIA1, GRIA2, GRIA3 and GRIA4). Can also open already desensitized GRIA1 receptors. Binds to a different site than does the drug cyclothiazide. The toxin acts like a straightjacket on the ligand-binding domain (LBD) gating ring of the receptor, restraining the domains via both intra- and interdimer cross-links such that agonist-ind |
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| Size | 0.01 mg (E-Coli), 0.01 mg (Yeast), 0.05 mg (E-Coli), 0.05 mg (Yeast), 0.1 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Con-ikot-ikot; Con-ikot-ikot] |
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| Gene, Accession, CAS # | Con-ikot-ikot, Accession: P0CB20.1 |
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| Catalog # | MBS1168053 |
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| Order / More Info | Recombinant Conus striatus Con-ikot-ikot from MYBIOSOURCE INC. |
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| Product Specific References | A novel Conus snail polypeptide causes excitotoxicity by blocking desensitization of AMPA receptors.Walker C.S., Jensen S., Ellison M., Matta J.A., Lee W.Y., Imperial J.S., Duclos N., Brockie P.J., Madsen D.M., Isaac J.T., Olivera B., Maricq A.V.Curr. Biol. 19:900-908(2009) X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism.Chen L., Durr K.L., Gouaux E.Science 345:1021-1026(2014) |
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