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| Product Name | EGF-L7, Recombinant, Human |
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| Description | Purity ≥98% by SDS-PAGE gel and HPLC analyses. EGF-L7 (Epidermal Growth Factor Like Protein 7, Multiple EGFLike Domains Protein 7, VE Statin) isa multi-domain protein containing two EGF like domains and oneEMI domain. It is expressed almost exclusively in endothelial cells andfunctions to promote normal development of the vascular system, particularlytubulogenesis. EGF-L7 is capable of antagonistic binding to Notch receptorsresulting in the inhibition of Notch signaling in HUVEC and neural stem cells.In research models inducing hypoxia and subsequent reoxygenation, (H/R), EGF-L7can inhibit ICAM-1 expression and enhance the inhibition of NF-kappaBactivation. Additionally, EGF-L7 can chemoattract endothelial cells and bind tothe extracellular matrix. The overexpression of EGF-L7 is observed in variouscancers, and is generally correlated with increased metastasis and a poorprognosis.nbsp Recombinant human EGF-L7 is a28kD protein containing 251 amino acid residues. AA Sequence: MYRPGRRVCA |
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| Size | 2ug, 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | EGF-L7, Recombinant, Human (Epidermal growth factor-like protein 7, MEGF7, Multiple EGF-like domains, protein 7, NOTCH4-like protein, VE-statin, Zneu1) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 143310 |
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| Order / More Info | EGF-L7, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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