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| Product Name | ErbB4, Recombinant, Human, His-Tag |
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| Description | Purity ~95% (SDS-PAGE). ErbB4, also known as Her4, is a member of the tyrosine kinase receptors (RTK) and the epidermal growth factor receptor (EGFR) subfamily, and appears to play important roles in differentiation, development and certain carcinomas. It is a single transmembrane-span type I glycoprotein structurally consisting of multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 (PI-3) kinase binding site and a PDZ domain binding motif. However, the last two domains are absent in one of the two naturally occurring ErbB4 isoforms, ErbB4 CYT-2. ErbB4 ligands include the neuregulins, betacellulin and heparin-binding EGF-like growth factor (HB-EGF). Typically, heterodimerization of ErbB4 with ErbB2 forms the high affinity receptor complex, and subsequently transmit cellular signals by activating downstream src homology-2 (SH2) and phosphotyrosine binding (PTB) domain-containing signaling molecules. ErbB4 undergoes sequential proces |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ErbB4, Recombinant, Human, His-Tag (Erythroblastic leukemia viral oncogene homolog 4, HER4, MGC138404, p180erbB4, ERBB4) |
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| Gene, Accession, CAS # | ERBB4, Gene ID: 2066, SwissProt: Q15303 |
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| Catalog # | 219729 |
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| Order / More Info | ErbB4, Recombinant, Human, His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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