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| Product Name | Erbb2, Recombinant, Mouse (Her2, Neu) |
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| Description | Purified (~90%). HER2/neu (also known as ErbB-2, ERBB2) is a protein (chromosome 17q21.1) highly expressed in breast cancers. It is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. The oncogene neu is so-named because it was derived from a neuroglioblastoma cell line in rat. ErbB2 was named for its similarity to ErbB (avian erythroblastosis oncogene B). Herstatin, as the product of alternative HER-2 transcript, retains intron 8. The herstatin mRNA is expressed in normal human fetal kidney and liver, but is at reduced levels relative to p185HER-2 mRNA in carcinoma cells that contain an amplified HER-2 gene. Herstatin appears to be an inhibitor of p185HER-2, because it disrupts dimers, reduces tyrosine phosphorylation of p185, and inhibits the anchorage-independent growth of transformed cells that over express HER-2. ERBB2 over expression confers resistance to taxol-induced apop |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P04626 |
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| Catalog # | 208881 |
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| Order / More Info | Erbb2, Recombinant, Mouse (Her2, Neu) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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