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| Product Name | Erbb2, Recombinant, Rat, Fc (Her2, Neu) |
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| Description | Highly Purified (~95%). HER2/neu (also known as ErbB-2, ERBB2) is a protein (protein accession # P04626; 1255aa, ~185kD, chromosome 17q21.1) highly expressed in breast cancers. It is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. The oncogene neu is so-named because it was derived from a neuroglioblastoma cell line in rat. ErbB2 was named for its similarity to ErbB (avian erythroblastosis oncogene B). Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's disease. Rat ErbB2 is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for rat ErbB2. It binds to the 5'-TCAAATTC-3' sequence in the MTCO2 promot |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: AAH61863.1, SwissProt: P04626 |
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| Catalog # | 208882 |
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| Order / More Info | Erbb2, Recombinant, Rat, Fc (Her2, Neu) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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