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| Product Name | Erbb2, Recombinant, Rhesus Monkey, His-Tag (Her2, Neu) |
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| Description | Highly Purified (~95%). HER2/neu (also known as ErbB-2, ERBB2) is a protein (protein accession # P04626; 1255aa, ~185kD, chromosome 17q21.1) highly expressed in breast cancers. It is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. The oncogene neu is so-named because it was derived from a neuroglioblastoma cell line in rat. ErbB2 was named for its similarity to ErbB (avian erythroblastosis oncogene B). Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's disease. ERBB2 over expression confers resistance to taxol-induced apoptosis by inhibiting p34(CDC2) activation. One mechanism is via ERBB2- mediated up regulation of p21(CIP1), or CDKN1A, which inhibits CDC2. Over expression also o |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: XP_001090430.1, SwissProt: P04626 |
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| Catalog # | 208885 |
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| Order / More Info | Erbb2, Recombinant, Rhesus Monkey, His-Tag (Her2, Neu) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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