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| Product Name | DDR2, Recombinant, Human (Discoidin Domain Receptor 2) |
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| Description | Purity ≥ 95%, as determined by SDS-PAGE and visualized by silver stain. DDR-2, also known as TYR010 and TKT, is a widely expressed 130kD type I transmembrane glycoprotein belonging to the discoidin-like domain containing subfamily of receptor tyrosine kinases (1). Mature human DDR-2 consists of a 378 aa extracellular domain (ECD) that includes the discoidin-like domain, a 22 aa transmembrane segment, and a 434 aa cytoplasmic domain that includes the kinase domain (2). Within the ECD, human DDR-2 shares 53% aa sequence identity with DDR-1 and 97% aa sequence identity with mouse DDR-2. The discoidin-like domain mediates DDR-2 interactions with collagens I, III, and X (3-5). Collagens II and V are less efficacious ligands (3). DDR-2 selectively recognizes the triple helical structure of collagen compared to monomeric or denatured collagen (3, 5, 6). Within collagen II, the D2 period is required for DDR-2 binding, and the D1 period is additionally required to trigger DDR-2 autophosphorylat |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q16832 |
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| Catalog # | D1650-02 |
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| Order / More Info | DDR2, Recombinant, Human (Discoidin Domain Receptor 2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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