| 产品详情 |
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| Product Name | Phenamil (methanesulfonate) |
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| Description | Purity >98%. Transient receptor potential polycystin-L (TRPP3) is a member of the TRP superfamily of cation channels that is localized to a subset of taste receptor cells in the tongue and to neurons surrounding the central canal of the spinal cord. Phenamil is a second generation analog of amiloride (hydrochloride) , the prototypical epithelial sodium channel (ENaC) blocker that inhibits TRPP3-mediated Ca2+ -activated currents with an IC50 value of 0.14 µM. It is also known to inhibit ENaC (IC50 = 10 nM). ENaC blockers such as phenamil have been proposed as a therapy to restore mucus clearance in cystic fibrosis airways. Phenamil inhibits active sodium transport of human and ovine bronchial epithelial cells with IC50 values of 75 and 116 nM, respectively. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3,5-diamino-6-chloro-N-[imino(phenylamino)methyl]-2-pyrazinecarboxamide, monomethanesulfonate |
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| Gene, Accession, CAS # | CAS: 1161-94-0 |
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| Catalog # | LS-H9373 |
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| Order / More Info | Phenamil (methanesulfonate) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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